Kimmel Cancer Center at Jefferson News Releases
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Therapy May Block Expansion of Breast Cancer Cells
Published: 11-07-2008
Summary
Breast cancer stem cells are known to be involved in therapy resistance and the recurrence of cancerous tumors. A new study appearing in Clinical and Translational Science shows the mechanisms governing stem cell expansion in breast cancer (called Notch activity), and finds that therapy targeting a protein called cyclin D1 may block the expansion of cancerous stem cells.
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Dr. Edith Mitchell Receives 'Tree of Life' Award
Published: 11-06-2008
Summary
Edith P. Mitchell, M.D., clinical professor, Department of Medical Oncology at Jefferson Medical College of Thomas Jefferson University and associate director of Diversity Programs for the Kimmel Cancer Center at Jefferson, was recently honored with a 'Tree of Life' award from The Wellness of You, a local nonprofit health education and resource organization.
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Lennox K. Black International Prize for Excellence in Biomedical Research
Published: 10-24-2008
Summary
Thomas Jefferson University is honoring Dr. Marshall, who is a Clinical Professor of Medicine at the University of Western Australia, with the Lennox K. Black International Prize for Excellence in Biomedical Research. Dr. Marshall will receive the award during a two-day symposium, Transformational Discoveries in Cancer. The symposium will be held November 10 and 11, and take place on the Jefferson campus at the Bluemle Life Sciences Building, 233 S. 10th Street.
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Dr. Baserga presents latest findings at the 7th International Symposium on Translational Research in Oncology
Published: 09-24-2008
Summary
Translational scientists from around the globe will assemble in Huntington Beach this October for the 7th International Symposium on Translational Research in Oncology. The program, developed by co-chairs Dennis J. Slamon M.D., Ph.D., and John Crown M.D., M.P.H., includes discussions on the latest translational research developments, to improve the clinical outcomes for cancer patients.
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Thomas Jefferson University Hospital Cancer Program Recognized by U.S. News & World Report
Published: 07-25-2008
Summary
Thomas Jefferson University Hospital's cancer program has recently been included in the U.S. News & World Report's 2008 list of America's Best Hospitals (28th).
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Jefferson Researchers Show Antibody to Breast Cancer-Secreted Protein Blocks Metastasis
Published: 07-07-2008
Summary
Scientists at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia have made a key discovery about the mechanism of breast cancer metastasis, the process by which cancer spreads. Focusing on a gene dubbed "Dachshund," or DACH1, they are beginning to pinpoint new therapeutic targets to halt the spread of cancer.
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Different Type of Colon Cancer Vaccine Reduces Disease Spread
Published: 06-24-2008
Summary
Taking advantage of the fact that the intestines have a separate immune system from the rest of the body, scientists at the Kimmel Cancer Center at Jefferson in Philadelphia have found a way to immunize mice against the development of metastatic disease.
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Blocking Signaling Protein Prevents Prostate Cancer Spread, Jefferson Scientists Find
Published: 06-18-2008
Summary
Researchers at the Kimmel Cancer Center at Jefferson in Philadelphia have shown that by blocking a signaling protein, they can prevent prostate cancer cells from metastatic dissemination. The work opens the door to future studies examining the protein as a target for therapies aimed at keeping prostate cancer at bay.
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Jefferson, Ohio State Team Find Gene Signature Profile for Metastasis
Published: 06-18-2008
Summary
A common signature of tiny, specific pieces of non-coding genetic material known as microRNAs (miRNAs) may be directly involved in the spread of cancer to other parts of the body. Researchers at the Kimmel Cancer Center at Jefferson in Philadelphia and Ohio State University Medical Center in Columbus have identified such a signature, made up mostly of overexpressed miRNAs. The findings, reported at the annual meeting of the American Society of Clinical Oncology in Chicago, may represent a novel diagnostic tool in characterizing gene targets in metastatic cancer.
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Monitoring Blood Flow Helps Improve Prostate Biopsies, Kimmel Cancer Center at Jefferson Researchers Report
Published: 06-03-2008
Summary
Using a special ultrasound technique to spot areas of blood flow in the prostate gland may substantially reduce the number of unnecessary biopsies, according to a new study by urologists and radiologists at the Jefferson Prostate Diagnostic Center and the Kimmel Cancer Center at Jefferson in Philadelphia. The researchers found that biopsies targeted to areas of increased blood flow in the prostate were twice as likely to be positive for cancer compared with conventional prostate biopsy techniques. They reported their initial results from a clinical trial this week at the annual meeting of the American Urological Association in Orlando.
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Traditional Herbal Medicine Kills Pancreatic Cancer Cells, Kimmel Cancer Center at Jefferson Researchers Report
Published: 05-23-2008
Summary
An herb used in traditional medicine by many Middle Eastern countries may help in the fight against pancreatic cancer, one of the most difficult cancers to treat. Researchers at the Kimmel Cancer at Jefferson in Philadelphia have found that thymoquinone, an extract of Nigella sativa seed oil, blocked pancreatic cancer cell growth and killed the cells by enhancing the process of programmed cell death.
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Kimmel Cancer Center Scientist Elected to Interurban Clinical Club
Published: 04-14-2008
Summary
Michael Lisanti, M.D., Ph.D., has recently been elected membership to the Interurban Clinical Club. This prestigious club was founded by Sir William Osler in 1905 for the purpose of exchanging ideas and fellowship among medical teachers in some of the leading Eastern medical schools.
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Jefferson Scientists' Discovery May Help Explain Smoking-Pancreatic Cancer Link
Published: 04-14-2008
Summary
Researchers at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia are inching closer to understanding how common blood pressure medications might help prevent the spread of pancreatic cancer. They have found in the laboratory that one type of pressure-lowering drug called an angiotensin receptor blocker inhibits pancreatic cancer cell growth and causes cell death.
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Neal Flomenberg, M.D., Named Chair of the Department of Medical Oncology at Jefferson
Published: 04-14-2008
Summary
Bone marrow transplant expert Neal Flomenberg, M.D., has been named the new chair of the Department of Medical Oncology at Jefferson Medical College of Thomas Jefferson University, Thomas Jefferson University Hospital and the Kimmel Cancer Center at Jefferson in Philadelphia.
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Blood Pressure Drugs Halt Pancreatic Cancer Cell Growth, Jefferson Researchers Find
Published: 04-14-2008
Summary
Researchers at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia are inching closer to understanding how common blood pressure medications might help prevent the spread of pancreatic cancer. They have found in the laboratory that one type of pressure-lowering drug called an angiotensin receptor blocker inhibits pancreatic cancer cell growth and causes cell death.
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Jefferson, PanCAN Holding Program April 5 to Help Patients, Families, and Public Learn More About Pancreatic Cancer
Published: 04-03-2008
Summary
Jefferson's Kimmel Cancer Center and the Pancreatic Cancer Action Network (PanCAN), a national advocacy organization, are sponsoring a pancreatic cancer symposium on Saturday, April 5, 2008 on the Thomas Jefferson University campus.
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Kimmel Cancer Center Hosts Program to Help Patients and Families Learn More About Living with Cancer April 2
Published: 04-01-2008
Summary
The Kimmel Cancer Center at Jefferson in Philadelphia is holding a program on Wednesday, April 2, 2008 for patients, families and caregivers whose lives have been touched by cancer.
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Kimmel Cancer Center Scientist Named Editor-in-Chief of Prestigious Pathology Journal
Published: 03-31-2008
Summary
Renowned cell biologist Michael P. Lisanti, M.D., Ph.D., the Margaret Q. Landenberger Professor in Breast Cancer Research at Jefferson Medical College of Thomas Jefferson University and the Kimmel Cancer Center at Jefferson in Philadelphia, has been named Editor-in-Chief of The American Journal of Pathology (AJP). His term begins in July.
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Jefferson Establishes New Center to Study Stem Cells and Regenerative Medicine
Published: 03-17-2008
Summary
Thomas Jefferson University has established a new center to study the biology, behavior and the potential medical uses of adult stem cells in a variety of diseases, including neurological disease and cancer.
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Blocking Growth Protein Kills Prostate Cancer Cells, Inhibits Tumor Growth, Jefferson Scientists Find
Published: 02-29-2008
Summary
Researchers at Jefferson's Kimmel Cancer Center in Philadelphia have shown that they can effectively kill prostate cancer cells in both the laboratory and in experimental animal models by blocking a signaling protein that is key to the cancer's growth. The work proves that the protein, Stat5, is both vital to prostate cancer cell maintenance and that it is a viable target for drug therapy.
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New Jefferson Trial to Test Radiation-Emitting Beads Against Advanced Liver Cancer
Published: 02-27-2008
Summary
Liver cancer specialists at Jefferson's Kimmel Cancer Center in Philadelphia are beginning an 18-month study of a new treatment for liver cancer. The therapy entails injecting tiny beads that emit small amounts of radiation into the liver's main artery while also blocking the blood supply feeding the cancer's growth.
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Kimmel Cancer Center Faculty Elected as Secretary of the Association of Cancer Executives (ACE)
Published: 02-27-2008
Summary
Joy Soleiman, MPA, Clinical Administrator of the Kimmel Cancer Center, was elected to a two year term as Secretary of the Association of Cancer Executives (ACE).
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Jefferson Scientists Uncover Role of Cancer Stem Cell Marker: Controlling Gene Expression Patterns
Published: 02-27-2008
Summary
Scientists at Jefferson's Kimmel Cancer Center in Philadelphia have made an extraordinary advance in the understanding of the function of a gene previously shown to be part of an 11-gene "signature" that can predict which tumors will be aggressive and likely to spread. The gene, USP22, encodes an enzyme that appears to be crucial for controlling large scale changes in gene expression, one of the hallmarks of cancer cells.